
I owe you a SIGNIFICANT debt.
Game of Thrones Season 3, Episode 3

Significant improvement
over the old neighbor.
The Big Bang Theory Season 1, Episode 1

last words are usually
as SIGNIFICANT as first words.
Game of Thrones Season 1, Episode 4

But there's been
a SIGNIFICANT reduction
in the tumors.
Breaking Bad Season 2, Episode 10

If I had another SIGNIFICANT aspect
of my life...
The Big Bang Theory Season 2, Episode 3